ZAP70

Zeta-Chain Associated Protein Kinase 70 kDa (ZAP70) is a group of proteins that attach to the zeta chain
components of T-cell receptors. ZAP70 is expressed in T-cells, natural killer (NK) cells, pro/pre B-cells but not in normal mature B-cells. Expression of ZAP70 has been reported in various lymphomas, including mantle cell lymphoma, small lymphocytic lymphoma, marginal zone lymphoma, and approximately 25% of chronic lymphocytic leukemia (CLL). In CLL, ZAP70 expression is closely associated with an unmutated configuration of the IgVH genes

Intended use

Anti-ZAP70 antibody is a useful aid for identification and classification of a subset of CLL and small lymphocytic lymphoma when used with a panel of other antibodies.

Specifications
product code: 8501-C010	Clone: EP122 [Rabbit]
Staining pattern: Cytoplasmic and/or nuclear staining	Control tissue: Tonsil
Assessment criteria
A moderate staining reaction of the majority of lymphocytes in the tonsil