SOX11

SOX11 is a nuclear transcription factor expressed in the developing human central nervous system and plays a role in embryonic cell determination. SOX11 is not expressed in normal adult human tissues. SOX11 over-expression is reported in over 90% of mantle cell lymphomas, including the rare cyclin D1 negative cases. SOX11 expression was also identified in some other tumors including malignant glioma, neuroendocrine carcinomas, sarcomas, adenocarcinomas, lymphoblastic leukemias /lymphomas, Burkitt lymphoma, hairy cell leukemia

Intended use

Anti-SOX11 antibody is useful for diagnosis of mantle cell lymphoma, particularly the rare cyclin D1 negative cases when used in a panel with other antibodies.

Specifications
product code: 8521-C010	Clone: GM032 [Mouse]
Staining pattern: Nuclear staining	Control tissue: Mantle cell lymphoma, Tonsil
Assessment criteria
The vast majority of neoplastic cells must show an as strong as possible nuclear staining reaction (a minimal cytoplasmic staining reaction must be accepted), while other cells must be negative in mantle cell lymphoma
No nuclear staining in tonsil
*A weak diffuse background staining can be accepted