Placental Alkaline Phosphatase (PLAP)

Placental Alkaline Phosphatase (PLAP) is a membrane-bound glycosylated dimeric enzyme expressed primarily in the placenta, and also in the endocervix and fallopian tubes. It is closely related to the intestinal form of the enzyme as well as to the placental-like form

Intended use

PLAP is useful for differentiating germ cell tumors such as seminomas and desmoplastic small round cell tumors from other neoplasms when used with a panel of antibodies.

Specifications
product code: 8235-C010	Clone: GM022 [Mouse]
Staining pattern: Membranous and/ or cytoplasmic staining	Control tissue: Placenta, Appendix
Assessment criteria
A strong predominantly membranous but also cytoplasmic staining reaction of the placental cytotrophoblasts and syncytiotrophoblasts with no or only a minimal reaction in the stromal cells
No structures/cells should show any staining reaction in appendix