OCT.2

OCT.2 is a transcription factor that binds to the immunoglobulin gene and interacts with BOB.1. It is essential for expression of B-cell specific genes. OCT.2 is expressed in mature B-cells, predominantly germinal center B-cells. High levels of OCT.2 expression was also found in monocytoid B-cells and plasma cells. Low expression has been found in immature B-cells, Tcells, epithelial cell lines, and myelomonocytic cells. Various lymphomas are also positive for this marker, including B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Tcell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin’s lymphoma, classic Hodgkin’s lymphoma.

Intended use

Anti-OCT.2 antibody is useful for differentiation of lymphoma, especially for identification of the lineage of CD20 negative B-cell neoplasms and differentiation of classical Hodgkin’s lymphoma from primary mediastinal large B-cell lymphoma when used in a panel with other antibodies. The strong nuclear
expression of BOB.1 and OCT.2 by germinal center derived lymphomas makes these antibodies a novel
class of broad-spectrum B-lineage IHC markers to aid in the differential diagnosis of lymphomas

Specifications
product code: 8334-C010	Clone: EP284 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Tonsil
Assessment criteria
A moderate to strong staining reaction of virtually all germinal centre B-cells in tonsil
A weak to moderate staining reaction is shown in mantle zone B-cells in the tonsil.