NKX3.1

NKX3.1 is an androgen-regulated tumor suppressor gene. NKX3.1 protein down regulate growth of epithelial cells in prostate tissue and plays a critical role in suppressing prostate carcinoma. NKX3.1 is expressed predominantly in prostate epithelium and is also found in testis, ureter, pulmonary bronchial mucous glands, salivary gland, and some cases of ductal and lobular breast carcinoma

Intended use

NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma. The anti-NKX3.1 antibody is useful for identifying neoplasm of prostate origin when used with a panel of other antibodies. It is particularly useful in low differentiated tumors where PSA and/or Prostein (P501S) may be weakly expressed or lost.

Specifications
product code: 8320-C010	Clone: EP356 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Prostate, Testis, Appendix
Associated panels: Carcinoma - general panel
Assessment criteria
A moderate to strong, distinct nuclear staining reaction of virtually all luminal epithelial cells of the hyperplastic prostate glands
An at least weak to moderate and distinct nuclear staining reaction of the majority of sertoli cells in seminiferous tubules of the testis
No nuclear staining reaction should be seen in epithelial cells of appendix