Granzyme B

Granzyme B is a serine protease expressed by cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. It induces apoptosis in target cells of these lymphocytes. A number of studies have demonstrated that the expression of granzyme B by immunohistochemistry in several entities of extra nodal peripheral T-cell lymphoma (PTCL) and NK-cell lymphomas, including nasal and nasal-type NK/T cell lymphomas, hepatosplenic and non-hepatosplenic PTCL, enteropathy-type (ETCL) and non-ETCL intestinal PTCL, subcutaneous panniculitis-like PTCL (SPTCL), cutaneous CD8+ epidermotropic lymphomas as well as in nodal and cutaneous CD30+ anaplastic large cell lymphomas (ALCL).

Intended use

The expression of cytotoxic proteins, such as granzyme B may aid in the identification and classification of extranodal T- and NK-cell lymphomas, since many of these tumors do not have specific morphology and phenotype, when used in a panel with other antibodies

Specifications
product code: 8234-C010	Clone: EP230 [Rabbit]
Staining pattern: Cytoplasmic staining	Control tissue: Tonsil
Assessment criteria
A moderate to strong staining reaction in T-lymphocytes in the high expressing tonsil.
A weak to moderate staining reaction in T-lymphocytes in the normal tonsil