Glial Fibrillary Acidic Protein (GFAP)

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed in astrocytes and ependymal cells. GFAP is also expressed in Schwann cells and satellite cells in sensory ganglia of the
peripheral nervous system, and in myoepithelial cells and chondroblasts. Immature oligodendrocytes and
choroid plexus cells may be GFAP positive. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always GFAP positive. Schwannoma and neurofibroma frequently express
GFAP

Intended use

Anti-GFAP antibody is useful for identifying astrocytes, differentiating primary gliomas from metastatic lesions in the brain, classifying intracranial tumors, and documenting astrocytic differentiation in tumors outside the central nervous system when used with a panel of other antibodies

Specifications
product code: 8316-C010	Clone: GA-5 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Brain
Assessment criteria
A strong and distinct cytoplasmic staining of the normal astrocytes in the brain
No staining in all other cells