CD71

CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells. Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes. CD71 is also regarded as a proliferation marker, and is expressed on myelocytes, activated B- and T-cells, thymocytes, macrophages, proliferating cells, and metabolically active cells, e.g. neurons, placental syncytiotrophoblasts, basal keratinocyte, hepatocyte, endocrine cells, and spermatocytes

Intended use

CD71 expression is observed in various neoplasms. The anti-CD71 antibody is useful for identifying erythroid precursors in bone marrow and diagnosing erythroid leukemia and benign erythroid proliferative disorders when used with a panel of other antibodies

Specifications
product code: 8322-C010	Clone: EP232 [Rabbit]
Staining pattern: Membranous staining	Control tissue: Tonsil, liver
Assessment criteria
A strong staining reaction of squamous epithelial cells in tonsil
At least a weak to moderate staining reaction of activated lymphocytes and germinal centre macrophages in tonsil
A weak staining reaction in dispersed lymphocytes in liver