CD61

CD61, also known as platelet glycoprotein IIIa (GPIIIa), is expressed in platelets and their precursors megakaryocytes, endothelium, endothelial cells, monocytes, smooth muscle cells, some B-cells, macrophages, mast cells, osteoclasts, and fibroblasts. The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation

Intended use

The anti-CD61 antibody is useful for identifying megakaryoblast differentiation and for classification of megakaryoblast leukemia when used in a panel with other antibodies

Specifications
product code: 8518-C010	Clone: ZM33 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Hyperplastic Bone Marrow, Tonsil
Assessment criteria
A weak to moderate staining reaction of megakaryocytes in AML’s
No staining in tonsil