CD14

CD14 is a membrane protein that primary is expressed on monocytes, macrophages, follicular dendritic cells, histiocytes, and Langerhans’ cells.

Intended use

CD14 is detected in myeloid leukemias with monoblastic/monocytic differentiation, histiocytic neoplasms, Langerhans' cell histiocytosis, and giant cell tumor. CD14 is more specific than CD68 in the identification of monocytes/histiocytes and the associated neoplasia. The anti-CD14 antibody is useful for classification of neoplastic cells of monocytic cell lineage when used with a panel of other antibodies.

Specifications
product code: 8321-C010	Clone: EP128 [Rabbit]
Staining pattern: Cytoplasmic and membranous	Control tissue: Appendix, liver
Assessment criteria
A strong and distinct cytoplasmic and membranous staining of follicular dendritic cells in the appendiceal germinal centres
A strong and distinct cytoplasmic and membranous staining of the macrophages in the lamina propria and in the germinal centres
A strong and distinct cytoplasmic and membranous staining of Kupffer cells in liver and the hepatic sinusoidal endothelial cells
No staining of enterocytes in appendix